It is believed that interstitial fluid pressure and solid stress are major obstacles preventing efficient delivery of macromolecules into tumor tissue, as well as stroma and an immunosuppressive tumor microenvironment.

One promising solution is to modulate the tumor microenvironment with biophysics using a combination of gas microspheres and ultrasound to introduce new cellular-level biophysical modes of action to work in concert with the molecular mechanism of action of a selected active drug. This effect can be limited to the target by aiming the ultrasound transducer and beam only at the tumor area to ensure total tumor coverage as well as treatment to the immediate periphery of tissue.

Vesselon’s Imagent® lipid microsphere can be co-formulated with any biologic macromolecules or with lipid nanoparticles and viral vectors to augment the biodistribution of these important drugs, without having to modify those drugs in any way.


  • Review the biophysical modes of action that work in concert to change the receive characteristics of tissue to augment receptivity to drugs.
  • Compare and contrast this platform to address multiple tissue types and tumor locations as well as multiple classes of drugs.
  • Explore how this platform technology can be employed to protect and expand existing drug franchises.
  • Examine the Regulatory Pathway possible with a platform that uses technology components that are all already approved for human use.
  • Discuss how this new pharmacology platform can fit within the existing clinical practice paradigm.